Patients with Addison's disease may experience weight loss due to:

In Addison's disease, there is an inadequate production of hormones by the adrenal glands, particularly cortisol. Cortisol plays a critical role in metabolism, energy regulation, and stress response. When cortisol levels are low, as seen in Addison's disease, patients can experience a range of symptoms, including weight loss.

Cortisol is essential for maintaining normal glucose levels and facilitating the metabolism of fats, proteins, and carbohydrates. In the absence of sufficient cortisol, the body struggles to appropriately manage energy resources, which can lead to decreased appetite and unintentional weight loss as the body breaks down its own tissues for energy.

Additionally, the energy deficit caused by low cortisol levels can lead to fatigue and weakness, further contributing to a reduced ability to maintain weight. This hormonal imbalance highlights why decreased cortisol levels are directly linked to the weight loss experienced by patients with Addison's disease.